Regulation of miRNA content. Part 1. Editing miRNA. Тailing miRNA
نویسندگان
چکیده
This scientific review presents the processes of regulation miRNA content. To write article, information was searched using Scopus, Web Science, MedLine, PubMed, Google Scholar, EMBASE, Global Health, The Cochrane Library, CyberLeninka databases. article characteristics microRNA editing and tailing, which regulate content through transcription control. It is emphasized that most important mechanism posttranscriptional occurs with help RNA-specific adenosine deaminase. shows leads to a change in secondary structure molecule deviation process maturation. shown tailing elongation tail by adding nucleotides 3’-end RNA. has been found uridinylation very common regulates gene expression. effect on biogenesis demonstrated example miR let-7 family, inhibits proliferation promotes cell differentiation. established another type namely adenylation, often contributes stabilization molecule, but some cases can lead degradation. Thus, carried out miRNA, tailing. Due editing, changes maturation deviates. MicroRNA post-transcriptional RNA polyuridinylation or polyadenylation. Uridinylation affects processing degradation precursors different molecular effects, contribute development diseases.
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ژورنال
عنوان ژورنال: CHILD`S HEALTH
سال: 2022
ISSN: ['2307-1168', '2224-0551']
DOI: https://doi.org/10.22141/2224-0551.16.4.2021.236911